Methotrexate

Name Methotrexate
Supplier Tocris Bioscience
Catalog 0582
Prices $115.00
Sizes 100 mg
Cas Number 59-05-2
Chemical Name N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamicacid
Formula C20H22N8O5
Molecular Weight 454.44
Purity >99 %
Description Cytotoxic agent. Inhibits thymidylate synthetase and de novo purine synthesis. Potent folic acid antagonist; inhibits dihydrofolate reductase. Also inhibits Ras carboxyl methylation in DKOB8 cells, leading to decreased p44 and Akt activation.
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Product References

The pharmacology and clinical use of methotrexate. - The pharmacology and clinical use of methotrexate.

Jolivet J, Cowan KH, Curt GA, Clendeninn NJ, Chabner BA. N Engl J Med. 1983 Nov 3;309(18):1094-104.

Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast - Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast

Allegra CJ, Hoang K, Yeh GC, Drake JC, Baram J. J Biol Chem. 1987 Oct 5;262(28):13520-6.

Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic - Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic

Chu E, Drake JC, Boarman D, Baram J, Allegra CJ. J Biol Chem. 1990 May 25;265(15):8470-8.

Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected - Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected

Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6529-34. Epub 2003 May 15.