Methoxy-X04

• Supplier: Tocris Bioscience
• Catalog: 4814
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Cas Number: 863918-78-9
• Chemical Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
• Formula: C23H20O3
• Molecular Weight: 344.4
• Purity: >98 %
• Description: Fluorescent amyloid β (A β ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (K i = 26.8 nM); binds selectively to fibrillar β -sheet deposits. Brain penetrant.

Product References

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and - Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and

Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT. J Neuropathol Exp Neurol. 2002 Sep;61(9):797-805.

Dynamics of the microglial/amyloid interaction indicate a role in plaque - Dynamics of the microglial/amyloid interaction indicate a role in plaque

Bolmont T, Haiss F, Eicke D, Radde R, Mathis CA, Klunk WE, Kohsaka S, Jucker M, Calhoun ME. J Neurosci. 2008 Apr 16;28(16):4283-92.

PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis - PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis

Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer MP, Heneka MT. J Neurosci. 2012 Nov 28;32(48):17321-31.