(±) -threo -3-Methylglutamic acid

Name (±) -threo -3-Methylglutamic acid
Supplier Tocris Bioscience
Catalog 0386
Prices $115.00, $485.00
Sizes 10 mg, 50 mg
Function Type Blocker
Cas Number 63088-04-0
Formula C6H11NO4
Molecular Weight 161.16
Purity >98 %
Description A potent blocker of glutamate transport; selective for EAAT2 and EAAT4 (IC 50 values are 90, 109, 1600 and 1080 μ M for EAAT2, EAAT4, EAAT1 and EAAT3 respectively).
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Product References

Contrasting modes of action of methylglutamate derivatives on the excitatory - Contrasting modes of action of methylglutamate derivatives on the excitatory

Vandenberg RJ, Mitrovic AD, Chebib M, Balcar VJ, Johnston GA. Mol Pharmacol. 1997 May;51(5):809-15.

Identification of functional domains of the human glutamate transporters EAAT1 - Identification of functional domains of the human glutamate transporters EAAT1

Mitrovic AD, Amara SG, Johnston GA, Vandenberg RJ. J Biol Chem. 1998 Jun 12;273(24):14698-706.

Pharmacological characterization of threo-3-methylglutamic acid with excitatory - Pharmacological characterization of threo-3-methylglutamic acid with excitatory

Eliasof S, McIlvain HB, Petroski RE, Foster AC, Dunlop J. J Neurochem. 2001 Apr;77(2):550-7.