( R )-(-)- α -Methylhistamine dihydrobromide

• Supplier: Tocris Bioscience
• Catalog: 0811
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 868698-49-1
• Chemical Name: (R)-(-)-α-Methyl-1H-imidazole-4-ethanaminedihydrobromide
• Formula: C6H11N3.2HBr
• Molecular Weight: 287
• Purity: >99 %
• Description: Very potent, high affinity H 3 agonist (K D = 50.3 nM) that displays > 200-fold selectivity over H 4 receptors. Inhibits H 3 -mediated histamine synthesis and release in the CNS and stimulates H 4 -mediated eosinophil shape change (EC 50 = 66 nM). Part of the Histamine H 3 Receptor Tocriset™ . ( S )-(+)- α -Methylhistamine dihydrobromide (Cat. No. 0572) also available.

Product References

Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist - Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist

Oishi R, Itoh Y, Nishibori M, Saeki K. J Neurochem. 1989 May;52(5):1388-92.

Characterization of histamine H3-receptors in guinea-pig ileum with H3-selective - Characterization of histamine H3-receptors in guinea-pig ileum with H3-selective

Hew RW, Hodgkinson CR, Hill SJ. Br J Pharmacol. 1990 Nov;101(3):621-4.

Plenary lecture. A third histamine receptor subtype: characterisation, - Plenary lecture. A third histamine receptor subtype: characterisation,

Schwartz JC, Arrang JM, Garbarg M, Pollard H. Agents Actions. 1990 Apr;30(1-2):13-23.

Histamine induces cytoskeletal changes in human eosinophils via the H(4) - Histamine induces cytoskeletal changes in human eosinophils via the H(4)

Buckland KF, Williams TJ, Conroy DM. Br J Pharmacol. 2003 Nov;140(6):1117-27. Epub 2003 Oct 6.