N α -Methylhistamine dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2342
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 16503-22-3
• Chemical Name: N-Methyl-1H-imidazole-4-ethanaminedihydrochloride
• Formula: C6H11N3.2HCl
• Molecular Weight: 198.09
• Description: Potent histamine agonist, particularly at H 3 receptors (potency relative to histamine is 81, 185, and 270% at H 1 , H 2 and H 3 respectively). Also displays agonist properties at H 4 receptors to which it binds with moderate affinity (K i = 23 nM).

Product References

Distribution, properties, and functional characteristics of three classes of - Distribution, properties, and functional characteristics of three classes of

Hill SJ. Pharmacol Rev. 1990 Mar;42(1):45-83.

Plenary lecture. A third histamine receptor subtype: characterisation, - Plenary lecture. A third histamine receptor subtype: characterisation,

Schwartz JC, Arrang JM, Garbarg M, Pollard H. Agents Actions. 1990 Apr;30(1-2):13-23.

Characterization of a digitonin-solubilized bovine brain H3 histamine receptor - Characterization of a digitonin-solubilized bovine brain H3 histamine receptor

Zweig A, Siegel MI, Egan RW, Clark MA, Shorr RG, West RE Jr. J Neurochem. 1992 Nov;59(5):1661-6.