Methyllycaconitine citrate

• Supplier: Tocris Bioscience
• Catalog: 1042
• Prices: $89.00, $375.00
• Sizes: 5 mg, 25 mg
• Function Type: Antagonist
• Cas Number: 112825-05-5
• Chemical Name: [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diolcitrate
• Formula: C37H50N2O10.C6H8O7
• Molecular Weight: 874.93
• Description: Potent antagonist for α 7-containing neuronal nicotinic receptors (K i = 1.4 nM). Interacts with α 4 β 2 and α 6 β 2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo .

Product References

Methyllycaconitine: a selective probe for neuronal alpha-bungarotoxin binding - Methyllycaconitine: a selective probe for neuronal alpha-bungarotoxin binding

Ward JM, Cockcroft VB, Lunt GG, Smillie FS, Wonnacott S. FEBS Lett. 1990 Sep 17;270(1-2):45-8.

Effects of Delphinium alkaloids on neuromuscular transmission. - Effects of Delphinium alkaloids on neuromuscular transmission.

Dobelis P, Madl JE, Pfister JA, Manners GD, Walrond JP. J Pharmacol Exp Ther. 1999 Nov;291(2):538-46.

Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: - Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum:

Escubedo E, Chipana C, Perez-Sanchez M, Camarasa J, Pubill D. J Pharmacol Exp Ther. 2005 Nov;315(2):658-67. Epub 2005 Aug 2.