Methylmalonate

• Supplier: Tocris Bioscience
• Catalog: 1029
• Prices: $49.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 516-05-2
• Chemical Name: 2-Methylpropanedioicacid
• Formula: C4H6O4
• Molecular Weight: 118.09
• Purity: >98 %
• Description: Intracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.

Product References

Methylmalonate toxicity in primary neuronal cultures. - Methylmalonate toxicity in primary neuronal cultures.

McLaughlin BA, Nelson D, Silver IA, Erecinska M, Chesselet MF. Neuroscience. 1998 Sep;86(1):279-90.

Experimental therapeutics in transgenic mouse models of Huntington's disease. - Experimental therapeutics in transgenic mouse models of Huntington's disease.

Beal MF, Ferrante RJ. Nat Rev Neurosci. 2004 May;5(5):373-84.

Huntington's disease and the striatal medium spiny neuron: cell-autonomous and - Huntington's disease and the striatal medium spiny neuron: cell-autonomous and

Ehrlich ME. Neurotherapeutics. 2012 Apr;9(2):270-84.