2-Methylthioadenosine diphosphate trisodium salt

• Supplier: Tocris Bioscience
• Catalog: 0566
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 475193-31-8
• Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogendiphosphate)trisodiumsalt
• Formula: C11H14N5Na3O10P2S
• Molecular Weight: 539.24
• Purity: >98 %
• Description: Potent purinergic agonist displaying selectivity for P2Y 1 , P2Y 12 and P2Y 13 receptors (pEC 50 = 8.29 and 9.05 for P2Y 1 and P2Y 12 , EC 50 = 19 nM for P2Y 13 ). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro .

Product References

2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the - 2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the

Macfarlane DE, Srivastava PC, Mills DC. J Clin Invest. 1983 Mar;71(3):420-8.

A retrospective of recombinant P2Y receptor subtypes and their pharmacology. - A retrospective of recombinant P2Y receptor subtypes and their pharmacology.

Sak K, Webb TE. Arch Biochem Biophys. 2002 Jan 1;397(1):131-6.

P2Y(13): identification and characterization of a novel Galphai-coupled ADP - P2Y(13): identification and characterization of a novel Galphai-coupled ADP

Zhang FL, Luo L, Gustafson E, Palmer K, Qiao X, Fan X, Yang S, Laz TM, Bayne M, Monsma F Jr. J Pharmacol Exp Ther. 2002 May;301(2):705-13.