Metyrapone

• Supplier: Tocris Bioscience
• Catalog: 3256
• Prices: $79.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 54-36-4
• Chemical Name: 2-Methyl-1,2-di-3-pyridinyl-1-propanone
• Formula: C14H14N2O
• Molecular Weight: 226.27
• Purity: >99 %
• Description: Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11- β hydroxylase (CYP11B1) activity (IC 50 = 7.83 μ M). Also inhibits CYP3A4 and cytochrome P450-mediated ω / ω -1 hydroxylase activity.

Product References

Structure-activity relationship study of the inhibition of adrenal cortical 11 - Structure-activity relationship study of the inhibition of adrenal cortical 11

Hays SJ, Tobes MC, Gildersleeve DL, Wieland DM, Beierwaltes WH. J Med Chem. 1984 Jan;27(1):15-9.

Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in - Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in

Asakura T, Shichi H. Exp Eye Res. 1992 Aug;55(2):377-84.

Structural and dynamical basis of broad substrate specificity, catalytic - Structural and dynamical basis of broad substrate specificity, catalytic

Park H, Lee S, Suh J. J Am Chem Soc. 2005 Oct 5;127(39):13634-42.