Mevastatin

Name Mevastatin
Supplier Tocris Bioscience
Catalog 3292
Prices $109.00, $459.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 73573-88-3
Chemical Name (2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenylbutanoate
Formula C23H34O5
Molecular Weight 390.52
Purity >98 %
Description Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo . Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Inactive lactam prodrug of mevastatin hydroxy acid, naturally bioactivated in vivo following oral administration.
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Product References

Effects of compactin, mevalonate and low-density lipoprotein on - Effects of compactin, mevalonate and low-density lipoprotein on

Cohen LH, Griffioen M, Havekes L, Schouten D, van Hinsbergh V, Kempen HJ. Biochem J. 1984 Aug 15;222(1):35-9.

Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates - Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates

Amin-Hanjani S, Stagliano NE, Yamada M, Huang PL, Liao JK, Moskowitz MA. Stroke. 2001 Apr;32(4):980-6.

HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of - HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of

Wachtershauser A, Akoglu B, Stein J. Carcinogenesis. 2001 Jul;22(7):1061-7.