| Name | MG 101 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4438 |
| Prices | $105.00 |
| Sizes | 5 mg |
| Function Type | Inhibitor |
| Cas Number | 110044-82-1 |
| Chemical Name | N-Acetyl-L-leucine-L-leucine-L-norleucinal |
| Formula | C20H37N3O4 |
| Molecular Weight | 383.53 |
| Description | Calpain inhibitor (IC 50 = 0.09 μ M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro . Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression. |
| Supplier Page | Shop |
Atencio IA, Ramachandra M, Shabram P, Demers GW. Cell Growth Differ. 2000 May;11(5):247-53.
Chatterjee PK, Brown PA, Cuzzocrea S, Zacharowski K, Stewart KN, Mota-Filipe H, McDonald MC, Thiemermann C. Kidney Int. 2001 Jun;59(6):2073-83.