MG 132

• Supplier: Tocris Bioscience
• Catalog: 3358
• Prices: $129.00
• Sizes: 5 mg
• Function Type: Inhibitor
• Cas Number: 133407-82-6
• Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
• Formula: C26H41N3O5
• Molecular Weight: 475.63
• Purity: >95 %
• Description: Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .

Product References

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 - The ubiquitin-proteasome pathway is required for processing the NF-kappa B1

Palombella VJ, Rando OJ, Goldberg AL, Maniatis T. Cell. 1994 Sep 9;78(5):773-85.

Differential inhibition of calpain and proteasome activities by peptidyl - Differential inhibition of calpain and proteasome activities by peptidyl

Tsubuki S, Saito Y, Tomioka M, Ito H, Kawashima S. J Biochem. 1996 Mar;119(3):572-6.

Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and - Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and

Banerjee D, Liefshitz A. Anticancer Res. 2001 Nov-Dec;21(6A):3941-7.