Mibefradil dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0997
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 116666-63-8
• Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylmethoxyacetoacetatedihydrochloride
• Formula: C29H38FN3O3.2HCl
• Molecular Weight: 568.56
• Purity: >97 %
• Description: Ca 2+ channel blocker with moderate selectivity for T-type Ca 2+ channels displaying IC 50 values of 2.7 μ M and 18.6 μ M for T-type and L-type channels respectively. Antihypertensive agent.

Product References

In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with - In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with

Osterrieder W, Holck M. J Cardiovasc Pharmacol. 1989 May;13(5):754-9.

Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, - Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem,

Veniant M, Clozel JP, Hess P, Wolfgang R. J Cardiovasc Pharmacol. 1991;18 Suppl 10:S55-8.

The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ - The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++

Mehrke G, Zong XG, Flockerzi V, Hofmann F. J Pharmacol Exp Ther. 1994 Dec;271(3):1483-8.