Milameline hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5539
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 139886-04-7
• Chemical Name: (E)-1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxaldehydeO-methyloximehydrochloride
• Formula: C8H14N2O.HCl
• Molecular Weight: 190.67
• Purity: >99 %
• Description: Muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (K i values are 2.3, 2.4, 3.6, 3.8 and 4.3 μ M for hM 1 , hM 2 , hM 3 , hM 4 and hM 5 receptors respectively). Cognitive enhancer; reverses spatial memory deficits in rats.

Product References

Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel - Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel

Sedman AJ, Bockbrader H, Schwarz RD. Life Sci. 1995;56(11-12):877-82.

Milameline (CI-979/RU35926): a muscarinic receptor agonist with - Milameline (CI-979/RU35926): a muscarinic receptor agonist with

Schwarz RD, Callahan MJ, Coughenour LL, Dickerson MR, Kinsora JJ, Lipinski WJ, Raby CA, Spencer CJ, Tecle H. J Pharmacol Exp Ther. 1999 Nov;291(2):812-22.

Functional comparison of muscarinic partial agonists at muscarinic receptor - Functional comparison of muscarinic partial agonists at muscarinic receptor

Wood MD, Murkitt KL, Ho M, Watson JM, Brown F, Hunter AJ, Middlemiss DN. Br J Pharmacol. 1999 Apr;126(7):1620-4.