Minocycline hydrochloride

Name Minocycline hydrochloride
Supplier Tocris Bioscience
Catalog 4762
Prices $95.00
Sizes 50 mg
Cas Number 13614-98-7
Chemical Name [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
Formula C23H27N3O7.HCl
Molecular Weight 493.94
Purity >98 %
Description Tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant.
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Product References

Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity - Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity

Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. J Neurosci. 2001 Apr 15;21(8):2580-8.

Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy - Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy

Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong VW. Brain. 2002 Jun;125(Pt 6):1297-308.

Minocycline prevents the development of neuropathic pain, but not acute pain: - Minocycline prevents the development of neuropathic pain, but not acute pain:

Padi SS, Kulkarni SK. Eur J Pharmacol. 2008 Dec 28;601(1-3):79-87.