MIRA-1

Name MIRA-1
Supplier Tocris Bioscience
Catalog 0583
Prices $109.00, $459.00
Sizes 10 mg, 50 mg
Cas Number 72835-26-8
Chemical Name 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione
Formula C8H9NO4
Molecular Weight 183.16
Description Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC 50 = 10 μ M).
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Product References

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by - Reactivation of mutant p53 and induction of apoptosis in human tumor cells by

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Strategies for therapeutic targeting of the p53 pathway in cancer. - Strategies for therapeutic targeting of the p53 pathway in cancer.

Wiman KG. Cell Death Differ. 2006 Jun;13(6):921-6.

p53 in breast cancer: mutation and countermeasures. - p53 in breast cancer: mutation and countermeasures.

Kumar S, Walia V, Ray M, Elble RC. Front Biosci. 2007 May 1;12:4168-78.