Mirin

• Supplier: Tocris Bioscience
• Catalog: 3362
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1198097-97-0
• Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
• Formula: C10H8N2O2S
• Molecular Weight: 220.25
• Purity: >99 %
• Description: Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC 50 = 12 μ M) and induces G 2 cell cycle arrest. Also blocks homology-directed repair in vitro .

Product References

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 - A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1

Dupre A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J. Nat Chem Biol. 2008 Feb;4(2):119-25.

Small molecule versus DNA repair nanomachine. - Small molecule versus DNA repair nanomachine.

Stivers JT. Nat Chem Biol. 2008 Feb;4(2):86-8.

Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 - Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1

Garner KM, Pletnev AA, Eastman A. Nat Chem Biol. 2009 Mar;5(3):129-30; author reply 130. doi: