Misoprostol

• Supplier: Tocris Bioscience
• Catalog: 2018
• Prices: $139.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 59122-46-2
• Chemical Name: (11α,13E)-(-)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oicacidmethylester
• Formula: C22H38O5
• Molecular Weight: 382.53
• Purity: >99 %
• Description: Cytoprotective prostaglandin E 1 analog that displays agonist activity at EP receptors. K i values are 120, 250, 67 and 67 nM at cloned mouse EP 1 , EP 2 , EP 3 and EP 4 receptors respectively. Prevents NSAID-induced gastric ulceration.

Product References

Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, - Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre,

Graham DY, Agrawal NM, Roth SH. Lancet. 1988 Dec 3;2(8623):1277-80.

Characterization of dilator prostanoid receptors in the fetal rabbit ductus - Characterization of dilator prostanoid receptors in the fetal rabbit ductus

Smith GC, Coleman RA, McGrath JC. J Pharmacol Exp Ther. 1994 Oct;271(1):390-6.

Ligand binding specificities of the eight types and subtypes of the mouse - Ligand binding specificities of the eight types and subtypes of the mouse

Kiriyama M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y, Narumiya S. Br J Pharmacol. 1997 Sep;122(2):217-24.