Mithramycin A

• Supplier: Tocris Bioscience
• Catalog: 2297
• Prices: $105.00
• Sizes: 1 mg
• Cas Number: 18378-89-7
• Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose
• Formula: C52H76O24
• Molecular Weight: 1085.16
• Purity: >95 %
• Description: Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg 2+ or Zn 2+ , inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

Product References

Mithramycin selectively inhibits transcription of G-C containing DNA. - Mithramycin selectively inhibits transcription of G-C containing DNA.

Miller DM, Polansky DA, Thomas SD, Ray R, Campbell VW, Sanchez J, Koller CA. Am J Med Sci. 1987 Nov;294(5):388-94.

Mithramycin selectively inhibits the transcriptional activity of a transfected - Mithramycin selectively inhibits the transcriptional activity of a transfected

Ray R, Thomas S, Miller DM. Am J Med Sci. 1990 Oct;300(4):203-8.

Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion. - Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.

Demicheli C, Garnier-Suillerot A. Biochem Biophys Res Commun. 1991 May 31;177(1):511-7.