Mitoglitazone

• Supplier: Tocris Bioscience
• Catalog: 4224
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Cas Number: 146062-49-9
• Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione
• Formula: C19H18N2O4S
• Molecular Weight: 370.42
• Purity: >98 %
• Description: Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPAR γ (EC 50 = 23.7 μ M).

Product References

Isolation and structure of a covalent cross-link adduct between mitomycin C and - Isolation and structure of a covalent cross-link adduct between mitomycin C and

Tomasz M, Lipman R, Chowdary D, Pawlak J, Verdine GL, Nakanishi K. Science. 1987 Mar 6;235(4793):1204-8.

Isolation and structure of an intrastrand cross-link adduct of mitomycin C and - Isolation and structure of an intrastrand cross-link adduct of mitomycin C and

Bizanek R, McGuinness BF, Nakanishi K, Tomasz M. Biochemistry. 1992 Mar 31;31(12):3084-91.