| Name | ML 228 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4748 |
| Prices | $209.00, $879.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Activator |
| Cas Number | 1357171-62-0 |
| Chemical Name | N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine |
| Formula | C27H21N5 |
| Molecular Weight | 415.49 |
| Purity | >98 % |
| Description | HIF pathway activator (EC 50 values are 1.23 and 1.4 μ M for HRE gene reporter assay and HIF-1 α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A 3 receptor, dopamine transporter, μ receptor, hERG and 5-HT 2B receptor, and rat sodium channel site 2, at a concentration of 10 μ M. |
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