| Name | ML 240 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4829 |
| Prices | $185.00, $755.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1346527-98-7 |
| Chemical Name | 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine |
| Formula | C23H20N6O |
| Molecular Weight | 396.44 |
| Purity | >99 % |
| Description | ATP-competitive inhibitor of p97 ATPase (IC 50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway. |
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