ML 277

• Supplier: Tocris Bioscience
• Catalog: 5153
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 1401242-74-7
• Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
• Formula: C23H25N3O4S2
• Molecular Weight: 471.59
• Purity: >98 %
• Description: Selective K v 7.1 (KCNQ1) potassium channel activator (EC 50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments I Ks current of cultured human cardiomyocytes and shortens action potential duration.

Product References

Identification of - Identification of

Mattmann ME, Yu H, Lin Z, Xu K, Huang X, Long S, Wu M, McManus OB, Engers DW, Le UM, Li M, Lindsley CW, Hopkins CR. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41. doi:

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological - Dynamic subunit stoichiometry confers a progressive continuum of pharmacological

Yu H, Lin Z, Mattmann ME, Zou B, Terrenoire C, Zhang H, Wu M, McManus OB, Kass RS, Lindsley CW, Hopkins CR, Li M. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8732-7. doi: