ML 297

• Supplier: Tocris Bioscience
• Catalog: 4976
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 1443246-62-5
• Chemical Name: N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
• Formula: C17H14F2N4O
• Molecular Weight: 328.32
• Purity: >99 %
• Description: Selective K ir 3.1/3.2 (GIRK1/2) channel activator (IC 50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, K ir 2.1 and K v 7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ -induced epileptic seizures in mice. Brain penetrant.

Product References

ML297 (VU0456810), the first potent and selective activator of the GIRK potassium - ML297 (VU0456810), the first potent and selective activator of the GIRK potassium

Kaufmann K, Romaine I, Days E, Pascual C, Malik A, Yang L, Zou B, Du Y, Sliwoski G, Morrison RD, Denton J, Niswender CM, Daniels JS, Sulikowski GA, Xie XS, Lindsley CW, Weaver CD. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86.

Discovery of 'molecular switches' within a GIRK activator scaffold that afford - Discovery of 'molecular switches' within a GIRK activator scaffold that afford

Wen W, Wu W, Romaine IM, Kaufmann K, Du Y, Sulikowski GA, Weaver CD, Lindsley CW. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4562-6.