ML 365

• Supplier: Tocris Bioscience
• Catalog: 5387
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 947914-18-3
• Chemical Name: 2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide
• Formula: C22H20N2O3
• Molecular Weight: 360.41
• Purity: >99 %
• Description: Potent and selective TASK-1 (K 2P 3.1/KCNK3) channel blocker (IC 50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at K ir 2.1, voltage-gated potassium channels, KCNQ2 and K V 11.1 (hERG).

Product References

ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two - ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two

Zou B, Flaherty DP, Simpson DS, Maki BE, Miller MR, Shi J, Wu M, McManus OB, Golden JE, Aube J, Li M.

Potent and selective inhibitors of the TASK-1 potassium channel through chemical - Potent and selective inhibitors of the TASK-1 potassium channel through chemical

Flaherty DP, Simpson DS, Miller M, Maki BE, Zou B, Shi J, Wu M, McManus OB, Aube J, Li M, Golden JE. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3968-73. doi: