ML 786 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4310
• Prices: $255.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 1237536-18-3
• Chemical Name: 3-(1-Amino-1-methylethyl)-N-[(2R)-1,2,3,4-tetrahydro-7-oxo-1,8-naphthryridin-4-yl)oxy]-2-naphthalenyl]-5-benzamidedihydrochloride
• Formula: C29H29F3N4O3.2HCl
• Molecular Weight: 611.48
• Purity: >98 %
• Description: Potent Raf kinase inhibitor (IC 50 values are 2.1, 2.5 and 4.2 nM for B-Raf V600E , C-Raf and wild-type B-Raf respectively). Also inhibits Abl-1, DDR2, EPHA2 and RET tyrosine kinase activity. Inhibits pERK formation and attenuates tumor growth in melanoma cell xenografts expressing the B-Raf V600E mutation in vivo . Orally bioavailable.

Product References

Design and optimization of potent and orally bioavailable tetrahydronaphthalene - Design and optimization of potent and orally bioavailable tetrahydronaphthalene

Gould AE, Adams R, Adhikari S, Aertgeerts K, Afroze R, Blackburn C, Calderwood EF, Chau R, Chouitar J, Duffey MO, England DB, Farrer C, Forsyth N, Garcia K, Gaulin J, Greenspan PD, Guo R, Harrison SJ, Huang SC, Iartchouk N, Janowick D, Kim MS, Kulkarni B, Langston SP, Liu JX, Ma LT, Menon S, Mizutani H, Paske E, Renou CC, Rezaei M, Rowland RS, Sintchak MD, Smith MD, Stroud SG, Tregay M, Tian Y, Veiby OP, Vos TJ, Vyskocil S, Williams J, Xu T, Yang JJ, Yano J, Zeng H, Zhang DM, Zhang Q, Galvin KM. J Med Chem. 2011 Mar 24;54(6):1836-46.