ML 9 hydrochloride

Name ML 9 hydrochloride
Supplier Tocris Bioscience
Catalog 5036
Prices $139.00, $585.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 105637-50-1
Chemical Name 1-(5-Chloronaphthalenesulfonyl)homopiperazinehydrochloride
Formula C15H17ClN2O2S.HCl
Molecular Weight 361.29
Purity >99 %
Description Selective MLCK inhibitor (K i values are 4, 32 and 54 μ M for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca 2+ entry (SOCE).
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Product References

Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and - Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and

Seto M, Sasaki Y, Hidaka H, Sasaki Y. Eur J Pharmacol. 1991 Mar 26;195(2):267-72.

Pharmacology of protein kinase inhibitors. - Pharmacology of protein kinase inhibitors.

Hidaka H, Kobayashi R. Annu Rev Pharmacol Toxicol. 1992;32:377-97.

STIM and Orai: the long-awaited constituents of store-operated calcium entry. - STIM and Orai: the long-awaited constituents of store-operated calcium entry.

Varnai P, Hunyady L, Balla T. Trends Pharmacol Sci. 2009 Mar;30(3):118-28.