ML SA1

• Supplier: Tocris Bioscience
• Catalog: 0431
• Prices: $105.00, $445.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 332382-54-4
• Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
• Formula: C22H22N2O3
• Molecular Weight: 362.42
• Purity: >99 %
• Description: Activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca 2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

Product References

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel - Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel

Shen D, Wang X, Li X, Zhang X, Yao Z, Dibble S, Dong XP, Yu T, Lieberman AP, Showalter HD, Xu H. Nat Commun. 2012 Mar 13;3:731.

Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. - Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases.

Weiss N. Commun Integr Biol. 2012 Mar 1;5(2):111-3.