Monastrol

Name Monastrol
Supplier Tocris Bioscience
Catalog 4115
Prices $169.00, $705.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 254753-54-3
Chemical Name 1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylicacid,ethylester
Formula C14H16N2O3S
Molecular Weight 292.35
Purity >98 %
Description Potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC 50 = 14 μ M).
Supplier Page Shop

Product References

Small molecule inhibitor of mitotic spindle bipolarity identified in a - Small molecule inhibitor of mitotic spindle bipolarity identified in a

Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Science. 1999 Oct 29;286(5441):971-4.

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of - Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of

Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ. J Cell Biol. 2000 Sep 4;150(5):975-88.