MP A08

• Supplier: Tocris Bioscience
• Catalog: 2282
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 219832-49-2
• Chemical Name: 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
• Formula: C27H25N3O4S2
• Molecular Weight: 519.64
• Description: Selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (K i values are 6.9 and 27 μ M, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro . Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

Product References

MPC-6827: a small-molecule inhibitor of microtubule formation that is not a - MPC-6827: a small-molecule inhibitor of microtubule formation that is not a

Kasibhatla S, Baichwal V, Cai SX, Roth B, Skvortsova I, Skvortsov S, Lukas P, English NM, Sirisoma N, Drewe J, Pervin A, Tseng B, Carlson RO, Pleiman CM. Cancer Res. 2007 Jun 15;67(12):5865-71.

Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent - Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent

Sirisoma N, Pervin A, Zhang H, Jiang S, Willardsen JA, Anderson MB, Mather G, Pleiman CM, Kasibhatla S, Tseng B, Drewe J, Cai SX. J Med Chem. 2009 Apr 23;52(8):2341-51.

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