8-M-PDOT

• Supplier: Tocris Bioscience
• Catalog: 0973
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 134865-70-6
• Chemical Name: 8-Methoxy-2-propionamidotetralin
• Formula: C14H19NO2
• Molecular Weight: 233.31
• Purity: >99 %
• Description: Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.

Product References

Melatonin receptors: are there multiple subtypes? - Melatonin receptors: are there multiple subtypes?

Dubocovich ML. Trends Pharmacol Sci. 1995 Feb;16(2):50-6.

Melatonin receptor antagonists that differentiate between the human Mel1a and - Melatonin receptor antagonists that differentiate between the human Mel1a and

Dubocovich ML, Masana MI, Iacob S, Sauri DM. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):365-75.

Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) - Pharmacological characterization of human recombinant melatonin mt(1) and MT(2)

Browning C, Beresford I, Fraser N, Giles H. Br J Pharmacol. 2000 Mar;129(5):877-86.