MPEP hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1035
• Prices: $139.00, $569.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 219911-35-0
• Chemical Name: 2-Methyl-6-(phenylethynyl)pyridinehydrochloride
• Formula: C14H11N.HCl
• Molecular Weight: 229.71
• Purity: >99 %
• Description: Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™ .

Product References

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically - 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically

Gasparini F, Lingenhohl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, Varney MA, Johnson EC, Hess SD, Rao SP, Sacaan AI, Santori EM, Velicelebi G, Kuhn R. Neuropharmacology. 1999 Oct;38(10):1493-503.

Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel - Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel

Salt TE, Binns KE, Turner JP, Gasparini F, Kuhn R. Br J Pharmacol. 1999 Jul;127(5):1057-9.

Positive allosteric modulation of the human metabotropic glutamate receptor 4 - Positive allosteric modulation of the human metabotropic glutamate receptor 4

Mathiesen JM, Svendsen N, Brauner-Osborne H, Thomsen C, Ramirez MT. Br J Pharmacol. 2003 Mar;138(6):1026-30.