2-MPPA

• Supplier: Tocris Bioscience
• Catalog: 1991
• Prices: $209.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 254737-29-6
• Chemical Name: 2-(3-Mercaptopropyl)pentanedioicacid
• Formula: C8H14O4S
• Molecular Weight: 206.26
• Description: Selective glutamate carboxypeptidase II (GCP II) inhibitor (IC 50 = 90 nM). Selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. Antinociceptive in a rat model of neuropathic pain and protects against motor neuron death in familial amyotrophic lateral sclerosis mice. Orally bioavailable.

Product References

Glutamate carboxypeptidase II inhibition protects motor neurons from death in - Glutamate carboxypeptidase II inhibition protects motor neurons from death in

Ghadge GD, Slusher BS, Bodner A, Canto MD, Wozniak K, Thomas AG, Rojas C, Tsukamoto T, Majer P, Miller RJ, Monti AL, Roos RP. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9554-9. Epub 2003 Jul 22.

Synthesis and biological evaluation of thiol-based inhibitors of glutamate - Synthesis and biological evaluation of thiol-based inhibitors of glutamate

Majer P, Jackson PF, Delahanty G, Grella BS, Ko YS, Li W, Liu Q, Maclin KM, Polakova J, Shaffer KA, Stoermer D, Vitharana D, Wang EY, Zakrzewski A, Rojas C, Slusher BS, Wozniak KM, Burak E, Limsakun T, Tsukamoto T. J Med Chem. 2003 May 8;46(10):1989-96.

Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II - Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II

Vornov JJ, Wozniak KM, Wu Y, Rojas C, Rais R, Slusher BS. J Pharmacol Exp Ther. 2013 Sep;346(3):406-13.