3-MPPI

• Supplier: Tocris Bioscience
• Catalog: 0853
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Cas Number: 133399-65-2
• Chemical Name: 2-[(4-Phenylpiperazin-1-yl)methyl]-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one
• Formula: C23H25N5O3
• Molecular Weight: 419.48
• Description: Very potent ligand for α 1 sites (K i for displacement of prazosin = 0.2 nM). Displays different binding properties for each α 1 subtype (pK i values are 8.74, 9.44 and 9.57 for α 1B , α 1D and α 1A adrenoceptors respectively). Also binds to 5-HT 1A sites (K i = 50 nM).

Product References

Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 - Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1

Russo F, Romeo G, Guccione S, De Blasi A. J Med Chem. 1991 Jun;34(6):1850-4.

New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes. - New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.

Romeo G, Materia L, Manetti F, Cagnotto A, Mennini T, Nicoletti F, Botta M, Russo F, Minneman KP. J Med Chem. 2003 Jul 3;46(14):2877-94.