Mps BAY 2a

• Supplier: Tocris Bioscience
• Catalog: 0783
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1382477-96-4
• Chemical Name: N-Cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
• Formula: C29H28N6O
• Molecular Weight: 476.57
• Purity: >98 %
• Description: Potent and selective Mps1 inhibitor (IC 50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.

Product References

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. - Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.

Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS. Nat Chem Biol. 2010 May;6(5):359-68.

A chemical tool box defines mitotic and interphase roles for Mps1 kinase. - A chemical tool box defines mitotic and interphase roles for Mps1 kinase.

Lan W, Cleveland DW. J Cell Biol. 2010 Jul 12;190(1):21-4.

High-throughput kinase profiling: a more efficient approach toward the discovery - High-throughput kinase profiling: a more efficient approach toward the discovery

Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS. Chem Biol. 2011 Jul 29;18(7):868-79.