MRK 560

• Supplier: Tocris Bioscience
• Catalog: 3817
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 677772-84-8
• Chemical Name: N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
• Formula: C19H17ClF5NO4S2
• Molecular Weight: 517.92
• Purity: >99 %
• Description: γ -secretase inhibitor; inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Reduces levels of A β in the brain (inhibits A β 40 and A β 42 in SH-SY5Y neuroblastoma cells with an IC 50 of 0.65 nM); attenuates plaque deposition. Orally bioavailable.

Product References

In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid - In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid

Best JD, Jay MT, Otu F, Churcher I, Reilly M, Morentin-Gutierrez P, Pattison C, Harrison T, Shearman MS, Atack JR. J Pharmacol Exp Ther. 2006 May;317(2):786-90. Epub 2006 Jan 27.

The novel gamma secretase inhibitor - The novel gamma secretase inhibitor

Best JD, Smith DW, Reilly MA, O'Donnell R, Lewis HD, Ellis S, Wilkie N, Rosahl TW, Laroque PA, Boussiquet-Leroux C, Churcher I, Atack JR, Harrison T, Shearman MS. J Pharmacol Exp Ther. 2007 Feb;320(2):552-8. Epub 2006 Nov 10.