MRS 1477

• Supplier: Tocris Bioscience
• Catalog: 1385
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 212200-21-0
• Chemical Name: 4-Ethyl-1,4-dihydro-5-[[(2-methoxyethyl)thio]carbonyl]-6-methyl-2-phenyl-3-pyridinecarboxylicacidethylester
• Formula: C21H27NO4S
• Molecular Weight: 389.51
• Purity: >98 %
• Description: TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin (Cat. No. 0462) in rats. Also prolongs capsaicin-induced hypothermia in mice.

Product References

Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of - Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of

Roh EJ, Keller JM, Olah Z, Iadarola MJ, Jacobson KA. Bioorg Med Chem. 2008 Oct 15;16(20):9349-58.

Small molecule positive allosteric modulation of TRPV1 activation by vanilloids - Small molecule positive allosteric modulation of TRPV1 activation by vanilloids

Kaszas K, Keller JM, Coddou C, Mishra SK, Hoon MA, Stojilkovic S, Jacobson KA, Iadarola MJ. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60.

Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. - Positive allosteric modulation of TRPV1 as a novel analgesic mechanism.

Lebovitz EE, Keller JM, Kominsky H, Kaszas K, Maric D, Iadarola MJ. Mol Pain. 2012 Sep 21;8:70.