MRS 1845

• Supplier: Tocris Bioscience
• Catalog: 2752
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 544478-19-5
• Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylicacidethyl,methylester
• Formula: C21H22N2O6
• Molecular Weight: 398.41
• Purity: >98 %
• Description: Potent blocker of store-operated Ca 2+ channels; inhibits capacitative Ca 2+ influx in HL-60 cells (IC 50 = 1.7 mM).

Product References

Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 - Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60

Harper JL, Camerini-Otero CS, Li AH, Kim SA, Jacobson KA, Daly JW. Biochem Pharmacol. 2003 Feb 1;65(3):329-38.

Depletion of calcium stores regulates calcium influx and signal transmission in - Depletion of calcium stores regulates calcium influx and signal transmission in

Szikra T, Cusato K, Thoreson WB, Barabas P, Bartoletti TM, Krizaj D. J Physiol. 2008 Oct 15;586(Pt 20):4859-75.

Calcium homeostasis and cone signaling are regulated by interactions between - Calcium homeostasis and cone signaling are regulated by interactions between

Szikra T, Barabas P, Bartoletti TM, Huang W, Akopian A, Thoreson WB, Krizaj D. PLoS One. 2009 Aug 21;4(8):e6723.