MRS 2179 tetrasodium salt

• Supplier: Tocris Bioscience
• Catalog: 1866
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1454889-37-2
• Chemical Name: 2'-Deoxy-N6-methyladenosine3',5'-bisphosphatetetrasodiumsalt
• Formula: C11H13N5O9P2Na4
• Molecular Weight: 513.16
• Purity: >98 %
• Description: A competitive antagonist at P2Y 1 receptors (K B = 100 nM). Selective over P2X 1 (IC 50 = 1.15 μ M), P2X 3 (IC 50 = 12.9 μ M), P2X 2 , P2X 4 , P2Y 2 , P2Y 4 and P2Y 6 receptors. Inhibits the upregulation of NTPDase1 by ATP γ S.

Product References

Competitive and selective antagonism of P2Y1 receptors by N6-methyl - Competitive and selective antagonism of P2Y1 receptors by N6-methyl

Boyer JL, Mohanram A, Camaioni E, Jacobson KA, Harden TK. Br J Pharmacol. 1998 May;124(1):1-3.

Synthesis, biological activity, and molecular modeling of ribose-modified - Synthesis, biological activity, and molecular modeling of ribose-modified

Nandanan E, Jang SY, Moro S, Kim HO, Siddiqui MA, Russ P, Marquez VE, Busson R, Herdewijn P, Harden TK, Boyer JL, Jacobson KA. J Med Chem. 2000 Mar 9;43(5):829-42.

Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate - Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate

Lu W, Reigada D, Sevigny J, Mitchell CH. J Pharmacol Exp Ther. 2007 Oct;323(1):157-64. Epub 2007 Jul 12.