MRS 2279

• Supplier: Tocris Bioscience
• Catalog: 1203
• Prices: $339.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 367909-40-8
• Chemical Name: (1R*,2S*)-4-[2-Chloro-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanoldihydrogenphosphateesterdiammoniumsalt
• Formula: C13H18ClN5O8P2.2NH3
• Molecular Weight: 503.78
• Purity: >98 %
• Description: Selective, high affinity competitive antagonist of the P2Y 1 receptor (K i = 2.5 nM; IC 50 = 51.6 nM). Fails to block nucleotide signaling at most other P2Y receptors (P2Y 2 , P2Y 4 , P2Y 6 , P2Y 11 and P2Y 12 ) and potently inhibits ADP-induced aggregation of human blood platelets in vitro (pK B = 8.05).

Product References

Synthesis, biological activity, and molecular modeling of ribose-modified - Synthesis, biological activity, and molecular modeling of ribose-modified

Nandanan E, Jang SY, Moro S, Kim HO, Siddiqui MA, Russ P, Marquez VE, Busson R, Herdewijn P, Harden TK, Boyer JL, Jacobson KA. J Med Chem. 2000 Mar 9;43(5):829-42.

2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a - 2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a

Boyer JL, Adams M, Ravi RG, Jacobson KA, Harden TK. Br J Pharmacol. 2002 Apr;135(8):2004-10.

2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane - 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane

Kim HS, Ohno M, Xu B, Kim HO, Choi Y, Ji XD, Maddileti S, Marquez VE, Harden TK, Jacobson KA. J Med Chem. 2003 Nov 6;46(23):4974-87.