MRS 2365

• Supplier: Tocris Bioscience
• Catalog: 2158
• Prices: $339.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 436847-09-5
• Chemical Name: [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl]diphosphoricacidmonoestertrisodiumsalt
• Formula: C13H16N5O9P2SNa3
• Molecular Weight: 549.28
• Purity: >98 %
• Description: Highly potent, selective P2Y 1 receptor agonist (EC 50 = 0.4 nM). Displays no activity at P2Y 12 receptors and only very low agonist activity at P2Y 13 receptors (at concentrations up to 1 μ M). Increases the upregulation of NTPDase1 by ATP γ S.

Product References

Adenine nucleotide analogues locked in a Northern methanocarba conformation: - Adenine nucleotide analogues locked in a Northern methanocarba conformation:

Ravi RG, Kim HS, Servos J, Zimmermann H, Lee K, Maddileti S, Boyer JL, Harden TK, Jacobson KA. J Med Chem. 2002 May 9;45(10):2090-100.

Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus - Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus

Chhatriwala M, Ravi RG, Patel RI, Boyer JL, Jacobson KA, Harden TK. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43. Epub 2004 Sep 2.

Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate - Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate

Lu W, Reigada D, Sevigny J, Mitchell CH. J Pharmacol Exp Ther. 2007 Oct;323(1):157-64. Epub 2007 Jul 12.