MRS 2500 tetraammonium salt

• Supplier: Tocris Bioscience
• Catalog: 2157
• Prices: $319.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 630103-23-0
• Chemical Name: (1R*,2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanoldihydrogenphosphateestertetraammoniumsalt
• Formula: C13H18N5O8P2I.4NH3
• Molecular Weight: 629.29
• Purity: >96 %
• Description: Highly potent and selective antagonist of the platelet P2Y 1 receptor (K i = 0.78 nM). Inhibits ADP-induced aggregation of human platelets with an IC 50 value of 0.95 nM. Inhibits the upregulation of NTPDase1 by ATP γ S. Prevents thrombus formation in vivo .

Product References

2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane - 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane

Kim HS, Ohno M, Xu B, Kim HO, Choi Y, Ji XD, Maddileti S, Marquez VE, Harden TK, Jacobson KA. J Med Chem. 2003 Nov 6;46(23):4974-87.

Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 - Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1

Cattaneo M, Lecchi A, Ohno M, Joshi BV, Besada P, Tchilibon S, Lombardi R, Bischofberger N, Harden TK, Jacobson KA. Biochem Pharmacol. 2004 Nov 15;68(10):1995-2002.

MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], - MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate],

Hechler B, Nonne C, Roh EJ, Cattaneo M, Cazenave JP, Lanza F, Jacobson KA, Gachet C. J Pharmacol Exp Ther. 2006 Feb;316(2):556-63. Epub 2005 Oct 19.

Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate - Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate

Lu W, Reigada D, Sevigny J, Mitchell CH. J Pharmacol Exp Ther. 2007 Oct;323(1):157-64. Epub 2007 Jul 12.