MRS 2578

• Supplier: Tocris Bioscience
• Catalog: 2159
• Prices: $109.00, $455.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 711019-86-2
• Chemical Name: N,N''-1,4-Butanediylbis[N'-(3-isothiocyanatophenyl)thiourea
• Formula: C20H20N6S4
• Molecular Weight: 472.66
• Purity: >95 %
• Description: Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

Product References

Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 - Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6

Mamedova LK, Joshi BV, Gao ZG, von Kugelgen I, Jacobson KA. Biochem Pharmacol. 2004 May 1;67(9):1763-70.

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. - UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.

Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, Tsuda M, Joshi BV, Jacobson KA, Kohsaka S, Inoue K. Nature. 2007 Apr 26;446(7139):1091-5. Epub 2007 Apr 4.

Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and - Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and

Kukulski F, Ben Yebdri F, Lefebvre J, Warny M, Tessier PA, Sevigny J. J Leukoc Biol. 2007 May;81(5):1269-75. Epub 2007 Feb 22.