MRS 3777 hemioxalate

Name MRS 3777 hemioxalate
Supplier Tocris Bioscience
Catalog 4260
Prices $159.00
Sizes 10 mg
Function Type Antagonist
Cas Number 1186195-57-2
Chemical Name 2-Phenoxy-6-(cyclohexylamino)purinehemioxalate
Formula C17H19N5O.½C2H2O4
Molecular Weight 354.39
Purity >98 %
Description High affinity adenosine A 3 receptor antagonist (K i = 47 nM) that displays > 200-fold selectivity versus A 1 , A 2A and A 2B receptors.
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Product References

"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 - "Reversine" and its 2-substituted adenine derivatives as potent and selective A3

Perreira M, Jiang JK, Klutz AM, Gao ZG, Shainberg A, Lu C, Thomas CJ, Jacobson KA. J Med Chem. 2005 Jul 28;48(15):4910-8.

Adenosine receptors as therapeutic targets. - Adenosine receptors as therapeutic targets.

Jacobson KA, Gao ZG. Nat Rev Drug Discov. 2006 Mar;5(3):247-64.

Progress in the pursuit of therapeutic adenosine receptor antagonists. - Progress in the pursuit of therapeutic adenosine receptor antagonists.

Moro S, Gao ZG, Jacobson KA, Spalluto G. Med Res Rev. 2006 Mar;26(2):131-59.