MRS 5698

• Supplier: Tocris Bioscience
• Catalog: 4261
• Prices: $339.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 1377273-00-1
• Chemical Name: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
• Formula: C28H23ClF2N6O3
• Molecular Weight: 564.97
• Purity: >96 %
• Description: High affinity and selective A 3 adenosine receptor agonist (K i ~ 3 nM); displays >1000-fold selectivity over A 1 and A 2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo . Orally bioavailable.

Product References

Structure-guided design of A(3) adenosine receptor-selective nucleosides: - Structure-guided design of A(3) adenosine receptor-selective nucleosides:

Tosh DK, Deflorian F, Phan K, Gao ZG, Wan TC, Gizewski E, Auchampach JA, Jacobson KA. J Med Chem. 2012 May 24;55(10):4847-60.

Endogenous adenosine A3 receptor activation selectively alleviates persistent - Endogenous adenosine A3 receptor activation selectively alleviates persistent

Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, Salvemini D. Brain. 2015 Jan;138(Pt 1):28-35.

Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly - Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly

Tosh DK, Padia J, Salvemini D, Jacobson KA. Purinergic Signal. 2015 Sep;11(3):371-87.