MRT 10

Name MRT 10
Supplier Tocris Bioscience
Catalog 5428
Prices $175.00, $709.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 330829-30-6
Chemical Name N-[[[3-Benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxybenzamide
Formula C24H23N3O5S
Molecular Weight 465.52
Purity >98 %
Description Smoothened (Smo) receptor antagonist (IC 50 = 0.5 μ M in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC 50 = 2.5 μ M); acts as an inverse agonist during nontranscriptional Hedgehog pathway activation (IC 50 = 2.5 μ M in HEK293 cells).
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Product References

Virtual screening-based discovery and mechanistic characterization of the - Virtual screening-based discovery and mechanistic characterization of the

Manetti F, Faure H, Roudaut H, Gorojankina T, Traiffort E, Schoenfelder A, Mann A, Solinas A, Taddei M, Ruat M. Mol Pharmacol. 2010 Oct;78(4):658-65.

Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog - Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog

Solinas A, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Mann A, Manetti F, Taddei M, Ruat M. J Med Chem. 2012 Feb 23;55(4):1559-71.