MRT 67307 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4585
• Prices: $189.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Chemical Name: N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamidedihydrochloride
• Formula: C26H36N6O2.2HCl
• Molecular Weight: 537.52
• Purity: >98 %
• Description: Salt inducible kinase (SIK) inhibitor (IC 50 values are 67, 250 and 430 nM for SIK2, SIK1 and SIK3 respectively). Also inhibits TBK1, MARK1-4, IKK ε and NUAK1 (IC 50 values are 19, 27-52, 160 and 230 nM respectively). Has no effect on IKK α or IKK β . Induces IL-10 secretion and inhibits TNF- α and IL-6 secretion in bacterial LPS-stimulated macrophages. Also enhances IL-1-induced activation of NF κ B-dependent gene transcription in mouse embryonic fibroblast (MEF) cells.

Product References

Novel cross-talk within the IKK family controls innate immunity. - Novel cross-talk within the IKK family controls innate immunity.

Clark K, Peggie M, Plater L, Sorcek RJ, Young ER, Madwed JB, Hough J, McIver EG, Cohen P. Biochem J. 2011 Feb 15;434(1):93-104.

The role of TBK1 and IKKepsilon in the expression and activation of Pellino 1. - The role of TBK1 and IKKepsilon in the expression and activation of Pellino 1.

Smith H, Liu XY, Dai L, Goh ET, Chan AT, Xi J, Seh CC, Qureshi IA, Lescar J, Ruedl C, Gourlay R, Morton S, Hough J, McIver EG, Cohen P, Cheung PC. Biochem J. 2011 Mar 15;434(3):537-48.

Phosphorylation of CRTC3 by the salt-inducible kinases controls the - Phosphorylation of CRTC3 by the salt-inducible kinases controls the

Clark K, MacKenzie KF, Petkevicius K, Kristariyanto Y, Zhang J, Choi HG, Peggie M, Plater L, Pedrioli PG, McIver E, Gray NS, Arthur JS, Cohen P. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. doi: