MRT 68601 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5134
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Chemical Name: N-[3-[[5-Cyclopropyl-2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamidehydrochloride
• Formula: C25H34N6O2.HCl
• Molecular Weight: 487.04
• Purity: >98 %
• Description: Potent TBK1 (TANK-binding kinase-1) inhibitor (IC 50 = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells.

Product References

2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin - 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin

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Effect of the 5-HT(6) serotonin antagonist MS-245 on the actions of (-)nicotine. - Effect of the 5-HT(6) serotonin antagonist MS-245 on the actions of (-)nicotine.

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Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human - Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human

Dukat M, Mosier PD, Kolanos R, Roth BL, Glennon RA. J Med Chem. 2008 Feb 14;51(3):603-11.