MTEP hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0854
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1186195-60-7
• Chemical Name: 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridinehydrochloride
• Formula: C11H8N2S.HCl
• Molecular Weight: 236.72
• Purity: >99 %
• Description: Potent, selective and non-competitive mGlu 5 antagonist (IC 50 = 5 nM in Ca 2+ -flux assay; K i = 16 nM). Displays anxiolytic activity in vivo and is orally active.

Product References

Reduced stress-induced hyperthermia in mGluR5 knockout mice. - Reduced stress-induced hyperthermia in mGluR5 knockout mice.

Brodkin J, Bradbury M, Busse C, Warren N, Bristow LJ, Varney MA. Eur J Neurosci. 2002 Dec;16(11):2241-4.

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective - 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective

Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L, Brodkin J, Jiang X, McDonald I, Rao S, Washburn M, Varney MA. J Med Chem. 2003 Jan 16;46(2):204-6.

Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist - Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist

Klodzinska A, Tatarczynska E, Chojnacka-Wojcik E, Nowak G, Cosford ND, Pilc A. Neuropharmacology. 2004 Sep;47(3):342-50.

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally - 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally

Roppe JR, Wang B, Huang D, Tehrani L, Kamenecka T, Schweiger EJ, Anderson JJ, Brodkin J, Jiang X, Cramer M, Chung J, Reyes-Manalo G, Munoz B, Cosford ND. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6.

Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy - Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy

Bradbury MJ, Campbell U, Giracello D, Chapman D, King C, Tehrani L, Cosford ND, Anderson J, Varney MA, Strack AM. J Pharmacol Exp Ther. 2005 Apr;313(1):395-402. Epub 2004 Dec 8.