NAB 2

• Supplier: Tocris Bioscience
• Catalog: 3905
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Cas Number: 1504588-00-4
• Chemical Name: N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
• Formula: C23H20ClN3O
• Molecular Weight: 389.88
• Purity: >98 %
• Description: Protects against α -synuclein toxicity. Reverses the α -synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. Promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.

Product References

Identification and rescue of alpha-synuclein toxicity in Parkinson - Identification and rescue of alpha-synuclein toxicity in Parkinson

Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schule B, Lippard SJ, Tsai LH, Krainc D, Buchwald SL, Jaenisch R, Lindquist S. Science. 2013 Nov 22;342(6161):983-7.

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates alpha-synuclein - Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates alpha-synuclein

Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S. Science. 2013 Nov 22;342(6161):979-83.